Acute reaction to combination shots, auto-immune reaction, sometimes occur in a small number of Weimaraner puppies. The first modified live virus shot may go smoothly, but the subsequent shots cause a severe immune system reaction from the puppy. Lethargy is noted which is rare for a puppy. A rising temperature, elevated white blood count, plus a lack of interest in food; the puppy may eat much less enthusiastically or not at all. The fever continues and lymph nodes swell. Swollen joints and weakness make the puppy unable to stand. A trip to the veterinarian is imperative. Treatment varies from giving large amounts of steroids to giving aspirin with antibiotics.

The Board of Directors of the Weimaraner Club of America recommends when vaccinating Weim puppies, the Distemper and Parvo shot vaccines be administered separately, a two week interval between each vaccine. Any other vaccines should be administered separately as well. While this protocol helps, it does not prevent the auto-immune response in all puppies. The shot schedule is more time consuming, but worth the effort.